Dit heb ik ook een keer voorgehad en blijkbaar had het iets te maken met het register (of zoiets) waar RTW niet uit was verwijderd.
Gevonden:
This answer is for an Advanced user. Please do not attempt the below solution if you are not comfortable editing the Registry. Damaging the Registry could result in very adverse effects to your system. USE AT YOUR OWN RISK.
If you are having problems uninstalling the game you can manually remove it from your machine. First it will be necessary to remove the registry keys the game creates. Please be cautious when working with the registry as it is very sensitive. Deleting the wrong thing can result in complete operating system failure.
1) Click Start then Run.
2) At the prompt type: REGEDIT. The registry editor will open.
3) Click the "+" next to HKEY_LOCAL_MACHINE.
4) Click the "+" next to SOFTWARE.
5) Click the "+" next to The Creative Assembly
6) Right-Click to delete the The Creative Assembly entry.
7) Click the "+" next to HKEY_CURRENT_USER.
8) Click the "+" next to SOFTWARE.
9) Click the "+" next to The Creative Assembly
10) Right-Click to delete the The Creative Assembly entry.
11) Close the registry editor.
Once the registry keys are removed, we'll need to remove the game files from your hard drive. These instructions assume you've installed the game in the default directory.
1) Double-click My Computer.
2) Double-click the C:\ drive.
3) Double-click Program Files.
4) Double-click Total War
4) Right-click on the Rome: Total War folder and choose delete.
Remove the RomeTW.ini file from your hard drive.
12) Click the Start button > Find (or Search) > Files & Folders.
13) Search your C:\ drive for a file named RomeTW.ini.
14) The file should be located in C:\WINDOWS.
15) Delete this file.
16) Reboot your machine. At this point the game is completely removed from your system
(Bron:
http://forums.totalwar.org/vb/showthread.php?t=43162)
